Author(s): RomeroAroca P, BagetBernaldiz M, FernandezBallart J, PlanaGil N, SolerLluis N,
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Abstract AIMS: To determine the 10-year incidence of diabetic retinopathy (DR) and macular edema (DME), and its relationship with its risk factors in a sample of type 1 diabetes mellitus. METHODS: A total of 334 patients without diabetic retinopathy at baseline underwent a 10-year prospective study, the risk factors included: age, gender, diabetes duration, HbA1c, LDL-C, HDl-C, TC/HDL-C ratio, ApoA1, ApoB, ApoB/ApoA1 ratio, and triglycerides were recorded. Risk factors for diabetic macular edema (DME) were also recorded. RESULTS: The 10-year incidence of any DR was 35.90\%, and 11.07\% developed DME. The risk factors for DR and DME were: diabetes duration, high glycosylated level, and arterial hypertension, and overt nephropathy was well correlated with DME. The lipid study demonstrated that ApoB/ApoA1 ratio was significant for any DR [HRR: 0.594 (0.416-0.848), p=0.01], and DME [HRR: 0.601 (0.433-0.894), p=0.009]. The TC/HDL ratio was only significant for DME [HRR: 0.624 (0.440-0.886), p=0.008]; other lipids values were not significant for any groups studied. CONCLUSIONS: In the present study, the ApoB/ApoA1 ratio was significant to the 10-year incidence of diabetic retinopathy and to macular edema; and the TC/HDL ratio was significant to a 10-year incidence of macular edema. Crown Copyright © 2011. Published by Elsevier Ireland Ltd. All rights reserved.
This article was published in Diabetes Res Clin Pract
and referenced in Journal of Clinical & Experimental Ophthalmology