Author(s): HJ Schmoll, K Jordan, R Huddart, M P Laguna, A Horwich, K Fizazi, V Kataja
The incidence of testicular cancer in Europe is rising, with doubling every 20 years. The current incidence is 63/100 000/year, with the highest rate in Northern European countries (68/100 000/year). The death rate is very low (3.8 cases/100 000/year). Of testicular tumours, 40% are seminomas and 60% non-seminomas. Invasive testicular cancer develops from carcinoma in situ (CIS)/testicular intraepithelial neoplasia (TIN), often found in the residual nonmalignant testicular tissue. In a random biopsy, 2%–5% of testicular cancer patients have CIS in the contralateral testis. This is in accordance with a 2%–3% rate of synchronous contralateral or metachronous testicular cancer.