alexa The 15\% rule in scleroderma: the frequency of severe organ complications in systemic sclerosis. A systematic review.
Immunology

Immunology

Rheumatology: Current Research

Author(s): Muangchan C Canadian Scl, Baron M, Pope J

Abstract Share this page

Abstract OBJECTIVE: The prevalence of organ complications in scleroderma (systemic sclerosis; SSc) varies by definition used. This study was done to determine the frequency of several features of SSc. METHODS: A search of Medline-Ovid/Embase, PubMed, and Scopus databases from 1980 to November 30, 2011, was conducted to identify relevant articles with at least 50 patients with SSc extracting prevalence of each organ complication. Study quality was assessed using the STROBE (Strengthening The Reporting of OBservational studies in Epidemiology) checklist. Pooled prevalence was calculated using the random effects method. Heterogeneity was quantified using I(2). RESULTS: A total of 5916 articles were identified (913 from Medline-Ovid/Embase, 1009 from PubMed, and 3994 from Scopus); 5665 were excluded, leaving 251 articles for full-text review, with 69 included. Where available, frequencies were also included from the Canadian Scleroderma Research Group. Many severe complications in SSc occur about 15\% of the time, including cardiac involvement (15\%, 95\% CI 6-24), diastolic dysfunction (16\%, 95\% CI 14-17), estimated pulmonary artery pressure > 40 mm Hg (18\%, 95\% CI 14-21), pulmonary arterial hypertension by right heart catheterization (15\%, 95\% CI 12-17), forced vital capacity (FVC) < 70\% predicted (15\%, 95\% CI 12-17), FVC < 80\% predicted (17\%, 95\% CI 12-21), myositis (13\%, 95\% CI 10-17), inflammatory arthritis (12\%, 95\% CI 9-16), Sjögren overlap (13\%, 95\% CI 10-16), and digital ulcers (DU; 15\%, 95\% CI 10-20); and 15\% of DU have complications (amputations 12\%, 95\% CI 8-16, and hospitalizations 13\%, 95\% CI 6-21). Scleroderma renal crisis is uncommon but occurs in almost 15\% (12\%, 95\% CI 5-19) of cases of disseminated cutaneous SSc. There is no 15\% rule within skin and gastrointestinal tract for SSc. CONCLUSION: The "15\%" rule for frequency of significant organ involvement in SSc is helpful. This article was published in J Rheumatol and referenced in Rheumatology: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords