alexa The association between mannose-binding lectin gene polymorphism and rheumatic heart disease.
Immunology

Immunology

Rheumatology: Current Research

Author(s): Messias Reason IJ, Schafranski MD, Jensenius JC, Steffensen R

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Abstract Mannan-binding lectin (MBL) is an innate pattern recognition molecule known to play a key role in pathogen clearance. As MBL2 gene polymorphism is associated to an increased susceptibility to infection, we aimed to determine genetic variations in the MBL2 gene in rheumatic heart disease (RHD). Genetic variations in the promoter and exon 1 region of the MBL2 gene were analyzed in 107 patients with RHD and 105 controls by real-time polymerase chain reaction. The frequency of MBL2* A/A genotype was significantly higher in RHD patients (71/107, 66.36\% vs 52/105, 49.52\%, p
  • DOI: 10.1016/j.humimm.2006.08.296
  • This article was published in Hum Immunol and referenced in Rheumatology: Current Research

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