alexa The BAFF APRIL system: emerging functions beyond B cell biology and autoimmunity.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Vincent FB, SaulepEaston D, Figgett WA, Fairfax KA, Mackay F

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Abstract The BAFF system plays a key role in the development of autoimmunity, especially in systemic lupus erythematosus (SLE). This often leads to the assumption that BAFF is mostly a B cell factor with a specific role in autoimmunity. Focus on BAFF and autoimmunity, driven by pharmaceutical successes with the recent approval of a novel targeted therapy Belimumab, has relegated other potential roles of BAFF to the background. Far from being SLE-specific, the BAFF system has a much broader relevance in infection, cancer and allergy. In this review, we provide the latest views on additional roles of the BAFF system in health and diseases, as well as an update on BAFF and autoimmunity, with particular focus on current clinical trials. Copyright © 2013 Elsevier Ltd. All rights reserved. This article was published in Cytokine Growth Factor Rev and referenced in Journal of Clinical & Cellular Immunology

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