Author(s): Chipuk JE, Moldoveanu T, Llambi F, Parsons MJ, Green DR
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Abstract B cell CLL/lymphoma-2 (BCL-2) and its relatives comprise the BCL-2 family of proteins, which were originally characterized with respect to their roles in controlling outer mitochondrial membrane integrity and apoptosis. Current observations expand BCL-2 family function to include numerous cellular pathways. Here we will discuss the mechanisms and functions of the BCL-2 family in the context of these pathways, highlighting the complex integration and regulation of the BCL-2 family in cell fate decisions.
This article was published in Mol Cell
and referenced in Journal of Molecular Biomarkers & Diagnosis