alexa The Brucella suis genome reveals fundamental similarities between animal and plant pathogens and symbionts.
General Science

General Science

Journal of Bioterrorism & Biodefense

Author(s): Paulsen IT, Seshadri R, Nelson KE, Eisen JA, Heidelberg JF,

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Abstract The 3.31-Mb genome sequence of the intracellular pathogen and potential bioterrorism agent, Brucella suis, was determined. Comparison of B. suis with Brucella melitensis has defined a finite set of differences that could be responsible for the differences in virulence and host preference between these organisms, and indicates that phage have played a significant role in their divergence. Analysis of the B. suis genome reveals transport and metabolic capabilities akin to soil/plant-associated bacteria. Extensive gene synteny between B. suis chromosome 1 and the genome of the plant symbiont Mesorhizobium loti emphasizes the similarity between this animal pathogen and plant pathogens and symbionts. A limited repertoire of genes homologous to known bacterial virulence factors were identified.
This article was published in Proc Natl Acad Sci U S A and referenced in Journal of Bioterrorism & Biodefense

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