alexa The CD28-related molecule ICOS is required for effective T cell-dependent immune responses.
Immunology

Immunology

Immunome Research

Author(s): Coyle AJ, Lehar S, Lloyd C, Tian J, Delaney T

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While CD28 is critical for expansion of naive T cells, recent evidence suggests that the activation of effector T cells is largely independent of CD28/B7. We suggest that ICOS, the third member of the CD28/CTLA-4 family, plays an important role in production of IL-2, IL-4, IL-5, and IFNgamma from recently activated T cells and contributes to T cell-dependent B help in vivo. Inhibition of ICOS attenuates lung mucosal inflammation induced by Th2 but not Th1 effector populations. Our data indicate a critical function for the third member of the CD28 family in T cell-dependent immune responses.

This article was published in Immunity. and referenced in Immunome Research

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