alexa The changing epidemiology of hepatitis B in the United States. Need for alternative vaccination strategies.
Infectious Diseases

Infectious Diseases

Journal of Infectious Diseases & Preventive Medicine

Author(s): Alter MJ, Hadler SC, Margolis HS, Alexander WJ, Hu PY,

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Abstract To determine trends in the incidence and epidemiology of acute hepatitis B in the United States we conducted intensive surveillance for viral hepatitis in four sentinel counties from October 1, 1981, to September 30, 1988. The overall incidence of hepatitis B remained relatively constant throughout the study period (average, 13.2 cases per 100,000 population), but disease transmission patterns changed significantly. The proportions of hepatitis B cases accounted for by homosexual activity and health care employment decreased 62\% and 75\%, respectively; the proportions of cases accounted for by parenteral drug use and heterosexual exposure increased 80\% and 38\%, respectively. The percentage of patients for whom no risk factor was identified (30\% to 40\%) did not change over time. These patients tended to belong to minority populations, and their socioeconomic level was low. The decline in the number of hepatitis B cases among homosexual men probably results from the modification of high-risk sexual behavior; the decline among health care workers is due mostly to hepatitis B immunization. The current strategy for prevention of hepatitis B, which targets high-risk groups for immunization, has failed to have a significant impact on the incidence of disease.
This article was published in JAMA and referenced in Journal of Infectious Diseases & Preventive Medicine

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