alexa The chemical repertoire of natural ribozymes.


Biochemistry & Physiology: Open Access

Author(s): Doudna JA, Cech TR

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Abstract Although RNA is generally thought to be a passive genetic blueprint, some RNA molecules, called ribozymes, have intrinsic enzyme-like activity--they can catalyse chemical reactions in the complete absence of protein cofactors. In addition to the well-known small ribozymes that cleave phosphodiester bonds, we now know that RNA catalysts probably effect a number of key cellular reactions. This versatility has lent credence to the idea that RNA molecules may have been central to the early stages of life on Earth. This article was published in Nature and referenced in Biochemistry & Physiology: Open Access

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