alexa The circuitry of a master switch: Myod and the regulation of skeletal muscle gene transcription.
Genetics

Genetics

Molecular Biology: Open Access

Author(s): Tapscott SJ, Tapscott SJ

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Abstract The expression of Myod is sufficient to convert a fibroblast to a skeletal muscle cell, and, as such, is a model system in developmental biology for studying how a single initiating event can orchestrate a highly complex and predictable response. Recent findings indicate that Myod functions in an instructive chromatin context and directly regulates genes that are expressed throughout the myogenic program, achieving promoter-specific regulation of its own binding and activity through a feed-forward mechanism. These studies are beginning to merge our understanding of how lineage-specific information is encoded in chromatin with how master regulatory factors drive programs of cell differentiation. This article was published in Development and referenced in Molecular Biology: Open Access

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