alexa The clinical significance of anti-beta-1 adrenergic receptor autoantibodies in cardiac disease.
Clinical Sciences

Clinical Sciences

Cardiovascular Pharmacology: Open Access

Author(s): Nussinovitch U, Shoenfeld Y, Nussinovitch U, Shoenfeld Y

Abstract Share this page

Abstract Autoimmune response against myocardial antigens is evident in numerous heart diseases. Both the induction of an autoimmune response and the pathogenesis of autoimmune heart diseases are not fully understood. The humoral immune response may play an important role via induction of cardiomyocyte apoptosis, alteration of myocardial mechanical and electrophysiological functions, and activation of the complement system and cell-mediated cytotoxicity. Anti-β-1 adrenergic receptor antibodies appear to contribute to the pathogenesis of dilated cardiomyopathy, heart failure, and Chagas disease. Herein, we review the current knowledge relating to anti-β-1 adrenergic receptor antibodies: their potential role in heart diseases and the potential benefits of a targeted therapy against their apparently destructive effects. Patients with dilated cardiomyopathy with circulating stimulatory anti-β-1 adrenergic receptor autoantibodies are probably at a higher risk for adverse outcome and should be treated with adrenergic receptor antagonists, and possibly with immunotherapy. Further research is required to determine which patients will gain additional clinical benefits from anti-autoantibody-targeted therapy. This article was published in Clin Rev Allergy Immunol and referenced in Cardiovascular Pharmacology: Open Access

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version