alexa The clinical significance of indomethacin-probenecid interaction.


Journal of Neuroinfectious Diseases

Author(s): Brooks PM, Bell MA, Sturrock RD, Famaey JP, Dick WC

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Abstract 1 The effect of the addition of probenecid to oral and rectal regimes of indomethacin was studied in three groups of rheumatoid arthritic patients. 2 The addition of probenecid increases plasma levels of indomethacin given both orally and rectally and significantly reduces the clinical parameters of joint inflammation. 3 The use of probenecid with indomethacin at night may be useful in reducing morning stiffness and pain. 4 Though indomethacin plasma levels are markedly raised during concurrent probenecid therapy remarkably few side effects were observed.
This article was published in Br J Clin Pharmacol and referenced in Journal of Neuroinfectious Diseases

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