alexa The co-expression of MMP-9 and Tenascin-C is significantly associated with the progression and prognosis of pancreatic cancer


Diagnostic Pathology: Open Access

Author(s): Xu Y, Li Z, Jiang P, Wu G, Chen K

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BACKGROUND: Matrix metalloproteinase-9 (MMP-9) and Tenascin-C (TN-C) have been shown to be involved in the metastasis of many tumors. The purpose of this study was to determine the relationship between the co-expression of these two molecules and the clinical prognosis of pancreatic cancer.

METHODS: We investigated the expression of TN-C and MMP-9 in 103 pancreatic cancer tissues by immunohistochemistry and used statistical analyses to investigate the correlations of individual expression or co-expression of these two molecules with clinicopathological parameters and survival of pancreatic cancer.

RESULTS: The expression of MMP-9 and TN-C were increased in pancreatic cancer. The co-expression of MMP-9 and TN-C was also detected. The expression of MMP-9 and TN-C were correlated with vascular invasion, lymph node invasion, liver metastases and TNM stage. The co-expression of MMP-9 and TN-C was significantly related to the pancreatic cancer metastases. The individual overexpression of MMP-9 or TN-C significantly decreased the overall survival rates. The co-expression of MMP-9 and TN-C had the lowest overall survival rates. The co-expression of MMP-9 and TN-C was an independent predictor of survival for pancreatic cancer patients.

CONCLUSIONS: Co-expression of MMP-9 and TN-C was associated with poorer prognosis and was found to be an independent predictor of survival.

This article was published in Diagnostic Pathology and referenced in Diagnostic Pathology: Open Access

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