alexa The common D302H variant of CASP8 is associated with risk of glioma.
Oncology

Oncology

Journal of Cancer Science & Therapy

Author(s): Bethke L, Sullivan K, Webb E, Murray A, Schoemaker M,

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Abstract Caspase 8 (CASP8) is a key regulator of apoptosis or programmed cell death, and, hence, a defense against cancer. We tested the hypothesis that the CASP8 polymorphism D302H influences risk of glioma through analysis of five series of glioma case patients and controls (n = 1,005 and 1,011, respectively). Carrier status for the rare allele of D302H was associated with a 1.37-fold increased risk (95\% confidence interval, 1.10-1.70; P = 0.004). The association of CASP8 D302H with glioma risk indicates the importance of inherited variation in the apoptosis pathway in susceptibility to this form of primary brain tumor. This article was published in Cancer Epidemiol Biomarkers Prev and referenced in Journal of Cancer Science & Therapy

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