Author(s): Sixt M, Kanazawa N, Selg M, Samson T, Roos G, , Sixt M, Kanazawa N, Selg M, Samson T, Roos G, , Sixt M, Kanazawa N, Selg M, Samson T, Roos G, , Sixt M, Kanazawa N, Selg M, Samson T, Roos G,
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Abstract Resident dendritic cells (DC) within the T cell area of the lymph node take up soluble antigens that enter via the afferent lymphatics before antigen carrying DC arrive from the periphery. The reticular network within the lymph node is a conduit system forming the infrastructure for the fast delivery of soluble substances from the afferent lymph to the lumen of high endothelial venules (HEVs). Using high-resolution light microscopy and 3D reconstruction, we show here that these conduits are unique basement membrane-like structures ensheathed by fibroblastic reticular cells with occasional resident DC embedded within this cell layer. Conduit-associated DC are capable of taking up and processing soluble antigens transported within the conduits, whereas immigrated mature DC occur remote from the reticular fibers. The conduit system is, therefore, not a closed compartment that shuttles substances through the lymph node but represents the morphological equivalent to the filtering function of the lymph node.
This article was published in Immunity
and referenced in Pharmaceutica Analytica Acta