alexa The correlation and reproducibility of histological scoring systems in cartilage repair.
Orthopaedics

Orthopaedics

Clinical Research on Foot & Ankle

Author(s): Moojen DJ, Saris DB, Auw Yang KG, Dhert WJ, Verbout AJ

Abstract Share this page

Abstract In recent years, the field of cartilage tissue engineering has seen a sharp increase in publications using many tissue engineering techniques and various analysis methods. Comparison between studies remains difficult, due to a lack of uniformity in methods used. A broad range of histological scoring systems is used to examine cartilage quality. Unfortunately, so far little is known on the reliability and correlation of these scoring systems. The objective of this study was to compare two frequently used cartilage repair grading scales, namely, the comprehensive O'Driscoll and the simple Pineda scale. We determined the intra- and interobserver variability of each score as well as the correlation between them. Thirty-eight joint section samples with variable cartilage quality were examined. Three observers documented their findings with both systems at two points in time. Statistical analysis showed very good intra- and interobserver reliability as well as a good correlation between the two scores. For the intraobserver variability of the O'Driscoll scale, we found an average difference of 0.05 with a SD of 0.93 in a 24-point score and a kappavalue of 0.87. For the interobserver reliability, the average difference was 0.001, SD 2.25, and a kappavalue of 0.92. The Pineda scale showed an average difference of 0.86 with a SD of 1.38 in a 14-point score and a kappavalue of 0.86 for the intraobserver reliability, whereas values for the interobserver reliability were average difference 0.82, SD 0.96, and a kappavalue of 0.89. The comparison between the two scales showed a high, inversely related correlation with a correlation coefficient of 0.71. From these results, we concluded that both the O'Driscoll and the Pineda scales are reliable semiquantitative cartilage scoring systems and that acceptance for general use of these two scores will benefit the reliability of literature on tissue engineering for cartilage repair. Thus, the added strength of comparison between published study results allows better understanding of cartilage repair publications and increases the impact of their results. This article was published in Tissue Eng and referenced in Clinical Research on Foot & Ankle

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 5th International Conference on Physiotherapy
    Nov 27-28, 2017, Dubai, UAE
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords