alexa The coupling of bone formation to bone resorption: a critical analysis of the concept and of its relevance to the pathogenesis of osteoporosis.
Immunology

Immunology

Journal of Clinical & Cellular Immunology

Author(s): Parfitt AM

Abstract Share this page

Abstract The approximate equality of whole-body rates of formation and resorption over a wide range, a phenomenon frequently but inaccurately referred to as coupling, depends on the prompt and approximately complete refilling of each new resorption cavity with new bone. This focal regulation of bone balance requires an adequate supply of new osteoblasts at the right place at the right time, a process which presumably depends both on the availability of precursor cells and on some form of coupling signal. It also requires that each new osteoblast is able to make a normal amount of bone matrix, a process which is probably unrelated to coupling. The defect in bone formation that occurs in normal aging (and is exaggerated in osteoporosis) is too small a total work output by each new team of osteoblasts, so that refilling of resorption cavities is incomplete. Whether too few osteoblasts are assembled, which could result from a defect in a coupling signal or from deficiency of osteoblast precursors, or whether each osteoblast makes a subnormal amount of bone is unknown. Defective coupling, in the sense of a delay in the focal onset of bone formation after completion of resorption does occur in many patients with osteoporosis but makes only a minor contribution to bone loss. Imbalance between whole-body rates of resorption and formation in the absence of a coupling defect can also result from exaggerated depth of resorption cavities leading to perforation of trabecular plates and removal of some of the surfaces on which new bone is formed. The possible role of defective coupling in the pathogenesis of osteoporosis is still to be established.
This article was published in Metab Bone Dis Relat Res and referenced in Journal of Clinical & Cellular Immunology

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords