alexa The diagnosis of mild cognitive impairment due to Alzheimer’s disease: Recommendations from the National Institute on Aging and Alzheimer’s Association workgroup
Medicine

Medicine

Journal of Gerontology & Geriatric Research

Author(s): Marilyn S Albert, Steven T DeKosky, Dennis Dickson, Bruno Dubois, Howard H Feldman, Nick C Fox, Anthony Gamst, David M Holtzman, William J Jagust, Ronald C Petersen, Peter J Snyder, Maria C Carrillo, Bill Thies, Creighton H Phelps

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The National Institute on Aging and the Alzheimer ’s Association charged a workgroup with the task of developing criteria for the symptomatic predementia phase of Alzheimer’s disease (AD), referred to in this article as mild cognitive impairment due to AD. The workgroup developed the following two sets of criteria: (1) core clinical c riteria that could be used by healthcare providers without access to advanced imaging techniques or cerebrospinal fluid analysis, and (2) research criteria that could be used in clinical research se ttings, including clinical trials. The second set of criteria incorporate the use of biomarkers base d on imaging and cerebrospinal fluid measures. The final set of criteria for mild cognitive impairment due to AD has four levels of certainty, depending on the presence and nature of the biom arker findings. Consider able work is needed to validate the criteria that use biomarkers and t o standardize biomarker analysis for use in community settings.

This article was published in Alzheimer’s & Dementia and referenced in Journal of Gerontology & Geriatric Research

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