Author(s): Zhang X, Zhang J, Tong L, Luo Y, Su M,
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Abstract A novel class of colchicine-SAHA hybrids were designed and synthesised based on the synergistic antitumor effect of tubulin inhibitors and histone deacetylases (HDAC) inhibitors. To the best of our knowledge, this is the first design of molecules that are dual inhibitors of tubulin and HDAC. Biological evaluations of these compounds included the inhibitory activity of HDAC, in vitro cell cycle analysis in BEL-7402 cells as well as cytotoxicity in five cancer cell lines. Copyright © 2013 Elsevier Ltd. All rights reserved.
This article was published in Bioorg Med Chem
and referenced in Medicinal Chemistry