Author(s): Lowther S, De Paermentier F, Crompton MR, Horton RW
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Abstract Total 5-HT1, 5-HT1D and 5-HT1E binding sites were measured in homogenates of human frontal cortex, hippocampus, amygdala, globus pallidus, caudate and putamen. Combined 5-HT1D/1E sites were the predominant 5-HT1 subtype (66-95\% of total 5-HT1 sites in all regions except hippocampus (38\% of total 5-HT1 sites). Globus pallidus contained the highest density and the highest proportion of 5HT1D sites (74\% of total 5-HT1 sites). 5HT1D sites in the other brain areas accounted for 19-27\% of the total 5-HT1 sites. The highest densities and the highest proportions of 5-HT1E sites were in caudate (72\%) and putamen (64\%) and the lowest density and lowest proportion in hippocampus (16\%).
This article was published in Eur J Pharmacol
and referenced in Journal of Genetic Syndromes & Gene Therapy
- Ruben Artero
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