Author(s): Gillman MA, Kimmel I, Lichtigfeld FJ
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Abstract We describe a dual-system hypothesis relating the seemingly contradictory findings reported in clinical and experimental investigations of pain. This incorporates a model in which two neuronal systems are related, involving Substance P (SP) and Enkephalin (E). This model uses feedback loops holding the systems in balance. The analogy to a control system is also made.
This article was published in Neurol Res
and referenced in Journal of Spine