alexa The Effect of Arsenic on Liver Tissue of Experimental Animals (Fishes and Mice) - A Review article
Biomedical Sciences

Biomedical Sciences

Biology and Medicine

Author(s): Kidanemariam Gaim, Girmay Gebru, Sunday Abba

Abstract Share this page

Toxic metals are widely found in our environment and are mainly caused by the use of the pesticides, industrial activities and mining operations. One of them is arsenic that accumulates in the liver tissue to toxic levels and cause changes in the activities of several liver enzymes and cellular damage. Enzymes like aspartate aminotransferase and alanine aminotransferase are found predominantly in liver tissue and cellular damage as a result of arsenic exposure releases these enzymes into the blood stream and the plasma levels of these enzymes indicate hepatotoxicity. The objective of this project is to review the several research works on the effect of arsenic on liver tissue of fishes and rats at different time of exposure.The resources used for this review were obtained from published work in several peer review journals. ALT activity has shown an increase of 6.03%, 13.61% and 27.75% at different doses of exposure and the AST has shown also an increase of 9.04%, 16.32% and 38.08% at different doses in fishes. The GDH activity has shows an increased level of 9.61%, 23.72% and 34.62% at different doses when compared to control groups of fishes. Varied degrees of changes (mild to severe) were also observed in groups of fishes and mice exposed to different doses of arsenic and results in necrosis of the hepatocytes, central vein and sinusoidal spaces expansion due to shrinkage. Other result has shown that fish exposed to different concentrations of NaAsO2 have shown varied degrees of changes i.e. death in high concentration; however, as the concentrations decreased, the survival period increased gradually. The FTIR spectra revealed also significant differences in absorbance intensities in the amide bands between control and arsenic intoxicated liver tissues. Among the results reported most of which have shown increment and some of them have shown decrement when compared to the control groups up on the exposure of different concentration of arsenic i.e. (28.30 mg/L of arsenic trioxide (As2O3), 4.2 mg/kg sodium arsenate, (96 ug/L, 144 ug/L), 1/10 LC50 of As, 1/20 LC50 of As, 75mg/L arsenic trioxide (AS2O3 ), (0.5,0.1 and 0.2mM of NaAsO2) and (41.5 ppb) of As2O3. Eventually, Arsenic administration increased serum AST and ALT activities of fishes reflecting a situation of tissue damage. This indicates that ALT and AST can be used as biomarkers of cellular damage in blood plasma, protein degradation and liver damage. In all the investigations various activities of arsenic on the enzymes may be related to the arsenic concentration, duration of the exposure, species differences and the methodology used

  • To read the full article Visit
  • Open Access
This article was published in International Journal of Scientific and Research Publications and referenced in Biology and Medicine

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords