Author(s): BALASUBRAMANIAM, K PRATHAP, KUALA LUMPUR, MALAYA
Spontaneous rupture of tendons has been reported in patients receiving either systemic or local steroid therapy. In most cases the patients were receiving systemic steroid therapy for rheumatoid arthritis, systemic lupus erythematosus or polyarteritis nodosa (Cowan and Alexander 1961, Lee 1961, Smaill 1961, Melmed 1965). Most of the tendon ruptures after local steroid infiltration occurred after muscular activity (Lee 1957; Ismail, Balakrishnan and Rajakumar 1969; Bedi and Ellis 1970). It seems certain that hydrocortisone plays at least some part in the tendon rupture (Sweetnam 1969) but there is no direct evidence to support this. The present study was undertaken to find out whether infiltration of steroid into the tendons of rabbits produces any damage to the tendons which may contribute to their rupture.