alexa The effect of timing of embryonic progression on chromosomal abnormality.
Genetics & Molecular Biology

Genetics & Molecular Biology

Human Genetics & Embryology

Author(s): Kroener L, Ambartsumyan G, BritonJones C, Dumesic D, Surrey M,

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Abstract OBJECTIVE: To evaluate the relationship between aneuploidy and timing of blastocyst formation. DESIGN: Historical cohort study. SETTING: Private IVF clinic. PATIENT(S): Ninety-four couples undergoing IVF treatment in combination with chromosomal screening of embryos. The mean maternal age was 39.2 years and average number of embryos per patient 5.3. INTERVENTION(S): A total of 530 embryos were biopsied on day 3 and underwent chromosome screening with microarray-based comparative genomic hybridization. MAIN OUTCOME MEASURE(S): Effect of day of embryo blastulation and morphologic grade on aneuploidy rate. RESULT(S): Day 5 morulas that progressed to blastocysts on day 6 were significantly less likely to be aneuploid (79.8\%) than day 5 morulas that did not progress to blastocysts (92.9\%). However, there was no significant difference in aneuploidy rates when embryos that became blastocysts on day 5 were directly compared with embryos that became blastocysts on day 6. CONCLUSION(S): Delayed blastulation is not associated with increased aneuploidy rates, but absence of blastulation is associated with increased aneuploidy. Therefore, we conclude that when choosing a morula for transfer on day 5, there may be a benefit in waiting an extra day for the possibility of blastulation to occur. Copyright © 2012 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. This article was published in Fertil Steril and referenced in Human Genetics & Embryology

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