alexa The effects of a vitamin D-deficient diet on chronic cadmium exposure in rats.
Materials Science

Materials Science

Journal of Material Sciences & Engineering

Author(s): Uchida H, Kurata Y, Hiratsuka H, Umemura T

Abstract Share this page

Abstract Itai-itai disease (IID) of humans is one of the most severe forms of chronic cadmium (Cd) intoxication. Itai-itai disease occurs mainly in post-menopausal women and is characterized by osteoporosis with osteomalacia, renal tubular disorder, and renal anemia. Some researchers insist the major cause of IID is not Cd, but rather malnutrition, especially hypovitaminosis D. We administrated a low concentration of Cd chloride intravenously to ovariectomized female rats that were fed a vitamin D-deficient diet or a normal diet for fifty weeks. The vitamin D-deficient diet decreased serum concentration of vitamin D, but it did not affect the metabolism of the kidney or bone. Cadmium treatment alone induced a decrease in serum concentration of vitamin D, as well as renal dysfunction, renal anemia, and abnormal bone metabolism. Osteoporosis with osteomalacia, tubular nephropathy, fibrous osteodystrophy, and bone marrow hyperplasia occurred following Cd treatment. In rats treated with Cd and administered a vitamin D-deficient diet, the toxic effects of Cd on kidney, bone, and hematopoiesis were enhanced in comparison to rats treated with Cd and a normal diet. The present experiment demonstrated that hypovitaminosis D did not evoke morphologic features of IID in humans but did enhance Cd-induced toxicity in the rat model of this disease. This article was published in Toxicol Pathol and referenced in Journal of Material Sciences & Engineering

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 10th International Conference on Advanced Materials and Processing
    August 16-17 Edinburgh, Scotland
  • 3rd International Conference on Polymer Science and Engineering
    October 2-4, 2017 Chicago, USA
  • International Conference on Advanced Materials and Nanotechnology
    October 26-28, 2017 Osaka, Japan
  • 13th International Conference and Exhibition on Materials Science and Engineering
    November 13-15, 2017 Las Vegas, Nevada, USA
  • 14th International Conference on Functional Energy Materials
    December 06-07, 2017 Atlanta, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version