Author(s): Rashidi B, Haghollahi F, Shariat M, Zayerii F
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Abstract OBJECTIVE: The aim of this study was to evaluate the effects of calcium-vitamin D and metformin on the menstrual cycle and ovulation in patients with polycystic ovary syndrome (PCOS). MATERIALS AND METHODS: In this pilot study, 60 infertile PCOS patients were enrolled in a randomized clinical trial and divided into three equal groups. Group 1 received 1,000 mg of calcium and 400 IU of vitamin D per day, orally. Group 2 received the same as Group 1, plus 1,500 mg/day of metformin. Group 3 received 1,500 mg/day of metformin. The patients were treated for 3 months and followed up for a further 3 months. Regularity of menses, number of large follicles (> or = 14 mm) and pregnancy rates were compared among the three groups. RESULTS: Generalized estimating equation tests showed that the number of dominant follicles (> or = 14 mm) during the 2-3 months of follow-up was higher in the calcium-vitamin D plus metformin group than in either of the other two groups (p = 0.03). CONCLUSION: The effects of metformin and calcium-vitamin D in regulating the menstrual cycle suggest that they could also be effective for the treatment of anovulation and oligomenorrhea, with possible consequences for pregnancy rates in PCOS patients.
This article was published in Taiwan J Obstet Gynecol
and referenced in Family Medicine & Medical Science Research