Author(s): Nation JR, Dugger LM, Dwyer KK, Bratton GR, Grover CA
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Abstract Sixteen adult male rats were presented with a diet containing no added lead (Group Control) or a diet containing 500 ppm inorganic lead (Group Lead) for 60 days. Subsequently, all animals were trained to lever press on an FR 1 reinforcement schedule for an ethanol reinforcer using a food-induction procedure where 20 g of food were presented to deprived animals 1 hr prior to the training session. Gradually, the daily food allotment was shifted to 15 min post-session and the ethanol concentration maintained at 6\% (v/v). On a subsequent dose/response test, serial presentations of 1, 2, 4, 8, 16, and 32\% ethanol reinforcement (v/v) were presented to both groups of animals. The results from the initial self-administration test using 6\% ethanol as the reward outcome showed that Group Lead lever pressed at a significantly lower rate than Group Control. In addition, on the dose/response test control animals increased responding at a lower concentration, and then as dose levels continued to increase, began to decrease responding earlier than lead-treated animals. Apparently, sensitivity to ethanol effects is decreased by lead toxicity. The importance of these data for understanding other metal/alcohol interactions is discussed.
This article was published in Alcohol Alcohol
and referenced in Journal of Addiction Research & Therapy