alexa The efficacy of various alloplastic bone grafts on the healing of rat calvarial defects.
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Tissue Science & Engineering

Author(s): Mah J, Hung J, Wang J, Salih E

Abstract Share this page

Abstract The objective of this study was to determine the relative efficacy of currently available alloplastic bone repair materials in the healing of rat calvarial defects histologically, histomorphometrically and biochemically. A representative material was selected from six major classes of bone repair materials and placed in 4 mm diameter calvarial defects of 6-week-old male Sprague-Dawley rats (five animals in the control and each of the six experimental groups). The outcomes were assessed after 2 months for alkaline phosphatase (ALP) activity and after 4 months of healing for histomorphometry. The tested alloplastic implant materials did not significantly increase ALP activity or the amount of new bone formation in the healing of rat calvarial defects relative to controls (P > 0.05). However, when the implant material itself was included in the analysis, significant differences were observed (P < 0.05). Additionally, the tested materials varied in their ability to bridge the bony defect. These data suggest that the rate of bone formation cannot be increased beyond control levels, rather the advantage of implant materials may be in their efficiency in filling the defect through incorporation of the material into the healing site and rapidly bridging the wound.
This article was published in Eur J Orthod and referenced in Journal of Tissue Science & Engineering

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 6th International Conference on Tissue Engineering and Regenerative Medicine
    August 23-24 , 2017 San Francisco, California ,USA
  • 8th International Conference on Tissue Science and Regenerative Medicine
    September 11-12, 2017 Singapore City, singapore
  • 9th Annual Conference on Stem Cell and Regenerative Medicine
    Sep 25-26, 2017 Berlin, Germany
  • 10th World Congress on Stem Cell and Biobanking
    October 23-24, 2017 Osaka, Japan

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version