alexa The emergence of lncRNAs in cancer biology.
Genetics & Molecular Biology

Genetics & Molecular Biology

Gene Technology

Author(s): Prensner JR, Chinnaiyan AM

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Abstract The discovery of numerous noncoding RNA (ncRNA) transcripts in species from yeast to mammals has dramatically altered our understanding of cell biology, especially the biology of diseases such as cancer. In humans, the identification of abundant long ncRNA (lncRNA) >200 bp has catalyzed their characterization as critical components of cancer biology. Recently, roles for lncRNAs as drivers of tumor suppressive and oncogenic functions have appeared in prevalent cancer types, such as breast and prostate cancer. In this review, we highlight the emerging impact of ncRNAs in cancer research, with a particular focus on the mechanisms and functions of lncRNAs.
This article was published in Cancer Discov and referenced in Gene Technology

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