Author(s): Gu B, Kelesidis T, Tsiodras S, Hindler J, Humphries RM
Abstract Share this page
Abstract The oxazolidinone antibiotic linezolid has demonstrated potent antimicrobial activity against Gram-positive bacterial pathogens, including methicillin-resistant staphylococci. This article systematically reviews the published literature for reports of linezolid-resistant Staphylococcus (LRS) infections to identify epidemiological, microbiological and clinical features for these infections. Linezolid remains active against >98\% of Staphylococcus, with resistance identified in 0.05\% of Staphylococcus aureus and 1.4\% of coagulase-negative Staphylococcus (CoNS). In all reported cases, patients were treated with linezolid prior to isolation of LRS, with mean times of 20.0 ± 47.0 months for S. aureus and 11.0 ± 8.0 days for CoNS. The most common mechanisms for linezolid resistance were mutation (G2576T) to the 23S rRNA (63.5\% of LRSA and 60.2\% of LRCoNS) or the presence of a transmissible cfr ribosomal methyltransferase (54.5\% of LRSA and 15.9\% of LRCoNS). The emergence of linezolid resistance in Staphylococcus poses significant challenges to the clinical treatment of infections caused by these organisms, and in particular CoNS.
This article was published in J Antimicrob Chemother
and referenced in Clinical Microbiology: Open Access