Author(s): Littler DR, Harrop SJ, Goodchild SC, Phang JM, Mynott AV,
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Abstract Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that they have both soluble and integral membrane forms. CLICs are highly conserved in chordates, with six vertebrate paralogues. CLIC-like proteins are found in other metazoans. CLICs form channels in artificial bilayers in a process favoured by oxidising conditions and low pH. They are structurally plastic, with CLIC1 adopting two distinct soluble conformations. Phylogenetic and structural data indicate that CLICs are likely to have enzymatic function. The physiological role of CLICs appears to be maintenance of intracellular membranes, which is associated with tubulogenesis but may involve other substructures. Copyright 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
This article was published in FEBS Lett
and referenced in Biochemistry & Analytical Biochemistry