alexa The epidemiology of HIV coreceptor tropism.


HIV: Current Research

Author(s): Hoffmann C, Hoffmann C

Abstract Share this page

Abstract According to their cellular coreceptor tropism, HIV variants are termed R5 if they use CCR5 as a coreceptor, whereas viruses with a preference for CXCR4 are termed X4. The prevalence of R5, X4 and dual/mixed (D/M) strains shows considerable variation in different patient populations. In treatment naive patients, R5 strains are found in 80-90\%, compared to only 50-55\% in patients with antiretroviral exposure. The most important predictor of R5 tropism seems to be a higher CD4 T-cell count in both naive and antiretrovirally pretreated patients. A low HIV plasma viremia seems to be associated with R5 tropism only in untreated patients. As the benefit of the new antiretroviral drug class of the CCR5 coreceptor antagonists will be probably limited to the HIV-infected patients harbouring R5 strains, determination of viral coreceptor tropism has become an important diagnostic prerequisite for the treatment of HIV infection. This review will focus on current knowledge of the epidemiology of HIV coreceptor tropism.
This article was published in Eur J Med Res and referenced in HIV: Current Research

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

1-702-714-7001Extn: 9037

Business & Management Journals


1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

1-702-714-7001 Extn: 9042

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version