Author(s): Jones PA, Baylin SB, Jones PA, Baylin SB
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Abstract Aberrant gene function and altered patterns of gene expression are key features of cancer. Growing evidence shows that acquired epigenetic abnormalities participate with genetic alterations to cause this dysregulation. Here, we review recent advances in understanding how epigenetic alterations participate in the earliest stages of neoplasia, including stem/precursor cell contributions, and discuss the growing implications of these advances for strategies to control cancer.
This article was published in Cell
and referenced in Journal of Cancer Science & Therapy