alexa The expression of MHC antigens by human teratocarcinoma derived cell lines
Genetics & Molecular Biology

Genetics & Molecular Biology

Journal of Stem Cell Research & Therapy

Author(s): Andrews PW

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We have used flow microfluorimetry to investigate quantitatively the expression of HLA-A, B and C antigens, and beta 2 microglobulin, by cell lines derived from human teratocarcinomas, Although low levels of these cell surface molecules were expressed by all the lines examined, there was no evidence of discrete HLA-A, B, C/beta 2-microglobulin positive and negative subpopulations in any cultures. In contrast, using similar techniques, no murine embryonal carcinoma cell line was found to express the homologous H-2 antigens, It is suggested that human embryonal carcinoma cells may differ from their mouse counterparts by expressing low levels of major histocompatibility antigens

This article was published in Tissue Antigens and referenced in Journal of Stem Cell Research & Therapy

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