alexa The expression of native and oxidized LDL receptors in brain microvessels is specifically enhanced by astrocytes-derived soluble factor(s).
Psychiatry

Psychiatry

Journal of Addiction Research & Therapy

Author(s): Lucarelli M, Borrelli V, Fiori A, Cucina A, Granata F,

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Abstract Ex vivo rat brain microvessels express receptors for native as well as for oxidized low-density lipoproteins. In brain microvessels-derived endothelial cells, the expression levels of both receptors were enhanced by co-cultivation with rat astrocytes, even in the absence of actual contact between the two cell types, suggesting a soluble factor(s)-based mechanism of induction. No modulation effect could be evidenced in a heterologous cellular system. Since both receptors were found to be expressed also in astrocytes, these cells are likely to contribute substantially to the lipoprotein management at the blood-brain barrier and in the brain compartment.
This article was published in FEBS Lett and referenced in Journal of Addiction Research & Therapy

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