alexa The first unprovoked, untreated seizure in childhood: a hospital based study of the accuracy of the diagnosis, rate of recurrence, and long term outcome after recurrence. Dutch study of epilepsy in childhood.
Neurology

Neurology

Journal of Neurology & Neurophysiology

Author(s): Stroink H, Brouwer OF, Arts WF, Geerts AT, Peters AC,

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Abstract OBJECTIVE: To assess the accuracy of the diagnosis of a first unprovoked seizure in childhood, the recurrence rate within two years, the risk factors for recurrence, and the long term outcome two years after recurrence. METHODS: One hundred and fifty six children aged 1 month to 16 years after a first seizure, and 51 children with a single disputable event were followed up. The diagnosis of a seizure was confirmed by a panel of three child neurologists on the basis of predescribed diagnostic criteria. None of the children was treated after the first episode. RESULTS: Five children with a disputable event developed epileptic seizures during follow up. The diagnosis did not have to be revised in any of the 156 children with a first seizure. The overall recurrence rate after two years was 54\%. Significant risk factors were an epileptiform EEG (recurrence rate 71\%) and remote symptomatic aetiology and/or mental retardation (recurrence rate 74\%). For the 85 children with one or more recurrences, terminal remission irrespective of treatment two years after the first recurrence was >12 months in 50 (59\%), This article was published in J Neurol Neurosurg Psychiatry and referenced in Journal of Neurology & Neurophysiology

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