alexa The Glu298ASP polymorphism of the endothelial nitric oxide synthase gene is associated with premature ST elevation myocardial infarction in Mexican population.
Medicine

Medicine

Journal of Medical Diagnostic Methods

Author(s): IsordiaSalas I, LeaosMiranda A, BorrayoSnchez G

Abstract Share this page

Abstract BACKGROUND: The polymorphism Glu298Asp of endothelial nitric oxide (eNOS) gene has been associated with hypertension and coronary artery disease in several populations worldwide, but results are still controversial. We examined the possible association of the Glu298Asp with premature ST elevation myocardial infarction (STEAMI) in young Mexican population. METHODS: In a case-control study 180 unrelated patients with STEAMI < or =45years who were admitted to a cardiovascular intense care unit and 180 apparently healthy controls matched by age and gender were recruited from January 2006 to June 2009. The polymorphism Glu298Asp was determined in all participants by a polymerase chain-reaction-restriction fragment length polymorphism assay (PCR-RFLP). RESULTS: There was a significant difference in the genotype distribution between 2 groups (P=0.001). The allele Asp occurred more frequently in the patients group (P=0.001). There were independent factors for STEAMI: the Asp allele (OR 2.2, 95\% CI 1.1-3.5, P=0.03), smoking (OR 5.0, 95\% CI 3.1-8.2, P<0.001), hypertension (OR 2.0, 95\% CI 1.0-3.5, P=0.03), family history of cardiovascular disease, (OR 3.7, 95\% CI 2.0-4.6, P=0.02), and dyslipidemia (OR 3.4, 95\% CI 2.0-6.3, P=0.02). CONCLUSIONS: The Asp allele from the Gu298Asp polymorphism represents an independent risk factor for premature STEAMI in Mexican Mestizo population. 2010 Elsevier B.V. All rights reserved. This article was published in Clin Chim Acta and referenced in Journal of Medical Diagnostic Methods

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Relevant Topics

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords