alexa The historical analysis of aspirin discovery, its relation to the willow tree and antiproliferative and anticancer potential.
Biochemistry

Biochemistry

Biochemistry & Physiology: Open Access

Author(s): Mahdi JG, Mahdi AJ, Mahdi AJ, Bowen ID

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Abstract For several millennia, the willow tree and salicin have been associated with salicylic acid, the key precursor molecule that has contributed to the discovery of acetylsalicylic acid, traded as aspirin. These molecules have been shown to possess phyto- and chemotherapeutic activities as analgesic drugs. In recent decades, aspirin has become the focus of extensive investigation into antiproliferative and anticancer activities. The historical steps that led to the discovery of aspirin, and its antiproliferative and anticancer potential are highlighted in this review. This article was published in Cell Prolif and referenced in Biochemistry & Physiology: Open Access

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