alexa The history of diclofenac.
Pharmaceutical Sciences

Pharmaceutical Sciences

Pharmaceutica Analytica Acta

Author(s): Sallmann AR

Abstract Share this page

Abstract The purpose in developing diclofenac sodium was to synthesize a nonsteroidal anti-inflammatory drug with high activity and outstanding tolerability. Factors considered were drug transport through biologic membranes, the atomic and spatial structure of the molecule, and the electronic structure. Based on analysis of other nonsteroidal anti-inflammatory drugs, it was postulated that an effective antirheumatic agent should have the following characteristics: an acidity constant between 4 and 5, a partition coefficient of approximately 10, and two aromatic rings twisted in relation to each other. The result was diclofenac sodium, which has an acidity constant of 4.0 and a partition coefficient of 13.4. The structural elements include a phenylacetic acid group, a secondary amino group, and a phenyl ring containing chlorine atoms, which cause maximum twisting of the ring. Experimental and clinical findings obtained to date have indicated that diclofenac sodium was synthesized on well-founded principles.
This article was published in Am J Med and referenced in Pharmaceutica Analytica Acta

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords