alexa The human microbiome as a reservoir of antimicrobial resistance.
General Science

General Science

Journal of Astrobiology & Outreach

Author(s): Penders J, Stobberingh EE, Savelkoul PH, Wolffs PF

Abstract Share this page

Abstract The gut microbiota is amongst the most densely populated microbial ecosystem on earth. While the microbiome exerts numerous health beneficial functions, the high density of micro-organisms within this ecosystem also facilitates horizontal transfer of antimicrobial resistance (AMR) genes to potential pathogenic bacteria. Over the past decades antibiotic susceptibility testing of specific indicator bacteria from the microbiome, such as Escherichia coli, has been the method of choice in most studies. These studies have greatly enlarged our understanding on the prevalence and distribution of AMR and associated risk factors. Recent studies using (functional) metagenomics, however, highlighted the unappreciated diversity of AMR genes in the human microbiome and identified genes that had not been described previously. Next to metagenomics, more targeted approaches such as polymerase chain reaction for detection and quantification of AMR genes within a population are promising, in particular for large-scale epidemiological screening. Here we present an overview of the indigenous microbiota as a reservoir of AMR genes, the current knowledge on this "resistome" and the recent and upcoming advances in the molecular diagnostic approaches to unravel this reservoir.
This article was published in Front Microbiol and referenced in Journal of Astrobiology & Outreach

Relevant Expert PPTs

Relevant Speaker PPTs

Recommended Conferences

  • 6th International Conference on Earth Science and Climate Change
    September 18-19, 2017 Hong Kong
  • 5th International Conference and Exhibition on Mechanical & Aerospace Engineering
    October 02-04, 2017 Las Vegas, Nevada, USA
  • 2nd International Convention on Geophysics and Geotechnics
    November 8-9, 2017 Las Vegas, Nevada, USA

Relevant Topics

Peer Reviewed Journals
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version