Author(s): Di Cesare A, Di Meglio P, Nestle FO, Di Cesare A, Di Meglio P, Nestle FO
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Abstract Abnormal production of inflammatory mediators is believed to play an important role in the pathogenesis of psoriasis. Emerging data, both in mice and in humans, put the spotlight on a new subset of T helper (Th) cells, in part characterized by their production of IL-17 and accordingly named Th17 cells. Here, we review the development, characterization, and function of human Th17 cells as well as the crucial role of IL-23 in the context of Th17-cell-dependent chronic inflammation in psoriasis. We further discuss recent clinical trials targeting the IL-23/Th17 axis in psoriasis.
This article was published in J Invest Dermatol
and referenced in Transcriptomics: Open Access