alexa The immunoinhibitory B7-H1 molecule as a potential target in cancer: killing many birds with one stone.


Brain Disorders & Therapy

Author(s): Afreen S, Dermime S

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Abstract Over expression of B7-H1 (also named PDL-1 or CD 274) molecule in cancer has been linked to worse prognosis and resistance to anti-cancer therapies in several malignancies. In this review, we update on the expression of B7-H1 molecule in solid and hematological malignancies. We also describe the possible mechanisms by which this molecule inhibits/downregulates the immune response to cancer cells. Finally, we highlight current and future potential therapeutic strategies that can be further developed to target this molecule. Copyright © 2013 King Faisal Specialist Hospital & Research Centre. Published by Elsevier B.V. All rights reserved. This article was published in Hematol Oncol Stem Cell Ther and referenced in Brain Disorders & Therapy

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