alexa The immunology of mitral valve stenosis
Infectious Diseases

Infectious Diseases

Journal of Clinical Infectious Diseases & Practice

Author(s): Rosa T Artola, Christos G Mihos, Orlando Santana

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Although the prevalence of rheumatic heart disease (RHD) has rapidly subsided over the last several decades in the United States, it still remains a serious cardiovascular disorder across the world, particularly in developing nations. Chronic autoimmune inflammation of the cardiac valves can result in mitral stenosis, increasing the risk of morbidity, mortality, and long-term sequelae in these patients. Researchers have begun to unravel the mysteries behind the development of RHD in the setting of chronic autoimmune inflammatory reactions and the roles genetic predisposition, antibody-and T-cell-mediated molecular mimicry, and cytokine proinflammatory responses play. In this article, the immunologic pathogenesis of RHD and its effects on the mitral valve are reviewed.

This article was published in International Journal of Interferon, Cytokine and Mediator Research and referenced in Journal of Clinical Infectious Diseases & Practice

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