alexa The immunomodulatory and antitumor activities of lectins from the mushroom Tricholoma mongolicum.
Bioinformatics & Systems Biology

Bioinformatics & Systems Biology

Metabolomics:Open Access

Author(s): Wang HX, Liu WK, Ng TB, Ooi VE, Chang ST

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Abstract TML-1 and TML-2 were two lectins isolated from the mushroom Tricholoma mongolicum. They did not differ appreciably in their pH stability and cationic requirement for hemagglutinating activity. They both stimulated the production of nitrite ions and activated the macrophages in mice. The two lectins were able to inhibit the growth of implanted sarcoma 180 cells by 68.84\% and 92.39\% respectively. The growth of tumor cells in the mouse peritoneal cavity was also inhibited by the two lectins with TML-2 expressing a greater potency.
This article was published in Immunopharmacology and referenced in Metabolomics:Open Access

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