Author(s): de Azevedo Paiva A, Rond PH, Rehder VazdeLima L, de Freitas Oliveira C, Ueda M,
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Abstract BACKGROUND & AIMS: To investigate the effect of vitamin A supplementation on parameters of the immune system of vitamin A-deficient children. METHODS: The study was carried out in four phases: 1) determination of serum retinol in 631 children from 36 to 83 months of age; 2) assessment of immunological markers [immunoglobulins and complement fractions, immunophenotyping of T and B lymphocytes, and natural killer (NK) cells], blood count, and serum ferritin of 52 vitamin A-deficient children (serum retinol < 0.70 micromol/L); 3) supplementation of the 52 deficient children with 200,000 IU of vitamin A; 4) determination of serum retinol and the immunological parameters 2 months after vitamin A supplementation. RESULTS: before vitamin A supplementation, 24.0 \% of the children were anemic and 4.3 \%had reduced ferritin concentrations. There was no significant difference between mean values of retinol according to the presence/absence of anemia. The mean values of the humoral and cellular immunological parameters did not show a statistically significant difference before and after supplementation with vitamin A. Children with concomitant hypovitaminosis A and anemia presented a significant increase in absolute CD4 and CD8 T-cell counts after vitamin A supplementation (p < 0.05). CONCLUSION: vitamin A had an effect on the recruitment of T and B lymphocytes to the circulation of children with hypovitaminosis A and anemia.
This article was published in Int J Vitam Nutr Res
and referenced in Journal of Cytology & Histology