alexa The incidence and nature of surgical adverse events in Colorado and Utah in 1992.
Pharmaceutical Sciences

Pharmaceutical Sciences

Clinical Pharmacology & Biopharmaceutics

Author(s): Gawande AA, Thomas EJ, Zinner MJ, Brennan TA

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Abstract BACKGROUND: Despite more than three decades of research on iatrogenesis, surgical adverse events have not been subjected to detailed study to identify their characteristics. This information could be invaluable, however, for guiding quality assurance and research efforts aimed at reducing the occurrence of surgical adverse events. Thus we conducted a retrospective chart review of 15,000 randomly selected admissions to Colorado and Utah hospitals during 1992 to identify and analyze these events. METHODS: We selected a representative sample of hospitals from Utah and Colorado and then randomly sampled 15,000 nonpsychiatric discharges from 1992. With use of a 2-stage record-review process modeled on previous adverse event studies, we estimated the incidence, morbidity, and preventability of surgical adverse events that caused death, disability at the time of discharge, or prolonged hospital stay. We characterized their distribution by type of injury and by physician specialty and determined incidence rates by procedure. RESULTS: Adverse events were no more likely in surgical care than in nonsurgical care. Nonetheless, 66\% of all adverse events were surgical, and the annual incidence among hospitalized patients who underwent an operation or child delivery was 3.0\% (confidence interval 2.7\% to 3.4\%). Among surgical adverse events 54\% (confidence interval 48.9\% to 58.9\%) were preventable. We identified 12 common operations with significantly elevated adverse event incidence rates that ranged from 4.4\% for hysterectomy (confidence interval 2.9\% to 6.8\%) to 18.9\% for abdominal aortic aneurysm repair (confidence interval 8.3\% to 37.5\%). Eight operations also carried a significantly higher risk of a preventable adverse event: lower extremity bypass graft (11.0\%), abdominal aortic aneurysm repair (8.1\%), colon resection (5.9\%), coronary artery bypass graft/cardiac valve surgery (4.7\%), transurethral resection of the prostate or of a bladder tumor (3.9\%), cholecystectomy (3.0\%), hysterectomy (2.8\%), and appendectomy (1.5\%). Among all surgical adverse events, 5.6\% (confidence interval 3.7\% to 8.3\%) resulted in death, accounting for 12.2\% (confidence interval 6.9\% to 21.4\%) of all hospital deaths in Utah and Colorado. Technique-related complications, wound infections, and postoperative bleeding produced nearly half of all surgical adverse events. CONCLUSION: These findings provide direction for research to identify the causes of surgical adverse events and for targeted quality improvement efforts. This article was published in Surgery and referenced in Clinical Pharmacology & Biopharmaceutics

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