alexa The influence of diabetes and hyperglycemia on clinical course after intracerebral hemorrhage.
Infectious Diseases

Infectious Diseases

Journal of AIDS & Clinical Research

Author(s): Passero S, Ciacci G, Ulivelli M, Passero S, Ciacci G, Ulivelli M

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Abstract OBJECTIVE: To determine whether diabetes and admission hyperglycemia in nondiabetic patients influence outcome and the occurrence of cerebral and medical complications after intracerebral hemorrhage (ICH). METHODS: The study sample included 764 patients with ICH. The effects of diabetes and admission hyperglycemia were examined in relation to 30-day and 3-month mortality using Cox regression models controlling for potential confounders. The analysis was conducted for the entire sample of patients and repeated in comatose and noncomatose patients. RESULTS: Among comatose patients, neither diabetes nor admission hyperglycemia contributed significant predictive information, as nearly all patients died. In noncomatose patients, diabetes was an independent predictor of 30-day (odds ratio [OR] 1.31; 95\% CI 1.08 to 1.58) and 3-month (OR 1.30; 95\% CI 1.08 to 1.56) mortality and was associated with a greater incidence of infectious (OR 1.24; 95\% CI 1.03 to 1.49) and cerebral (OR 1.42; 95\% CI 1.10 to 1.83) complications. Among nondiabetic patients with Glasgow Coma Scale score of >8, hyperglycemia was an independent predictor of 30-day (OR 1.29; 95\% CI 1.05 to 1.58) and 3-month (OR 1.27; 95\% CI 1.05 to 1.53) mortality and was associated with a greater incidence of cerebral complications (OR 1.47; 95\% CI 1.12 to 2.94). CONCLUSIONS: Both diabetes and admission hyperglycemia in nondiabetic patients are predictors of poor outcome after supratentorial ICH. This may be related to the greater incidence of cerebral and infectious complications in diabetic patients and of cerebral complications in hyperglycemic nondiabetic patients.
This article was published in Neurology and referenced in Journal of AIDS & Clinical Research

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