alexa The inherited basis of diabetes mellitus: implications for the genetic analysis of complex traits.
Genetics

Genetics

Journal of Clinical & Medical Genomics

Author(s): Florez JC, Hirschhorn J, Altshuler D

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Abstract Diabetes encompasses a heterogeneous group of diseases, each with a substantial genetic component. We review the division of diabetes into different subtypes based on clinical phenotype, the fruitful pursuit of genes underlying monogenic forms of the disease, the successes and drawbacks of whole-genome linkage scans in type 1 and type 2 diabetes, and the recent identification of several diabetes genes by large association studies. We use the lessons learned from this extensive body of evidence to illustrate general implications for the genetic analysis of complex traits. This article was published in Annu Rev Genomics Hum Genet and referenced in Journal of Clinical & Medical Genomics

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