alexa The inhibitory effect of polyphenols on human gut microbiota.
Food & Nutrition

Food & Nutrition

Journal of Probiotics & Health

Author(s): DudaChodak A

Abstract Share this page

Abstract The intestinal microbiota (IM) is responsible for metabolism of many compounds provided in the diet, such as polyphenols, increasing their bioavailability. However, there are remarkably few studies investigating the influence of polyphenols on the composition and activity of the gut microbial community. This study evaluated the influence of the polyphenols naringenin (N), naringin (NR), hesperetin (H), hesperidin (HR), quercetin (Q), rutin (QR), and catechin (CAT) on the growth of human IM representatives (Bacteroides galacturonicus, Lactobacillus sp., Enterococcus caccae, Bifidobacterium catenulatum, Ruminococcus gauvreauii, Escherichia coli). Polyphenols were added to liquid medium at a final concentration of 20, 100 or 250 μg/ml (for Q concentrations were 4, 20 or 50 μg/ml) and their impact on the IM was assessed by measurement of the turbidity after 24-h culture. The minimal inhibitory concentration (MIC) for polyphenols that inhibited bacteria was estimated. CAT had no impact on the tested IM. Q had the strongest impact on R. gauvreauii, B. galacturonicus and Lactobacillus sp. (MIC 20-50 μg/ml) growth, whilst its rutinoside had no impact. NR and HR had no impact, but their aglycones N and H inhibited growth of almost all analyzed bacteria (MIC ≥250 μg/ml). We conclude that flavonoid aglycones, but not their glycosides, may inhibit growth of some intestinal bacteria. This means that polyphenols probably can modulate the IM and indirectly interfere with their own bioavailability.
This article was published in J Physiol Pharmacol and referenced in Journal of Probiotics & Health

Relevant Expert PPTs

Relevant Speaker PPTs

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]micsonline.com

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords